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Protoplasma. 2012 Jul;249(3):459-67. doi: 10.1007/s00709-011-0305-2. Epub 2011 Jul 24.

Centrins in unicellular organisms: functional diversity and specialization.

Author information

1
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore.

Abstract

Centrins (also known as caltractins) are conserved, EF hand-containing proteins ubiquitously found in eukaryotes. Similar to calmodulins, the calcium-binding EF hands in centrins fold into two structurally similar domains separated by an alpha-helical linker region, shaping like a dumbbell. The small size (15-22 kDa) and domain organization of centrins and their functional diversity/specialization make them an ideal system to study protein structure-function relationship. Here, we review the work on centrins with a focus on their structures and functions characterized in unicellular organisms.

PMID:
21786168
DOI:
10.1007/s00709-011-0305-2
[Indexed for MEDLINE]

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