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Biochem Biophys Res Commun. 1990 Feb 28;167(1):301-9.

Fission yeast cdc25 is a cell-cycle regulated protein.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.

Abstract

Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2/M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2.

PMID:
2178610
DOI:
10.1016/0006-291x(90)91765-k
[Indexed for MEDLINE]

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