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Chem Soc Rev. 2012 Jan 7;41(1):242-57. doi: 10.1039/c1cs15080d. Epub 2011 Jul 22.

Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer.

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ENSCPB, Université Bordeaux 1, 33607 Pessac, France.


This critical review focuses on the anti-cancer fight using gold nanoparticles (AuNPs) functionalized with chemotherapeutic drugs in so-called "complexes" (supramolecular assemblies) and "conjugates" (covalent assemblies) as vectors. There is a considerable body of recent literature on various tumor-imaging techniques using the surface plasmon band (SPB) and the "passive" and "active" vectorization of anti-cancer drugs. This article reviews the main concepts and the most recent literature data with emphasis on AuNP preparation, cytotoxicities and use in selective targeting of cancer cells with over-expressed receptors for diagnosis and therapy (108 references).

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