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Mediators Inflamm. 2011;2011:560194. doi: 10.1155/2011/560194. Epub 2011 Jul 13.

Novel interventional approaches for ALI/ARDS: cell-based gene therapy.

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1
Department of Pulmonary Medicine, Huadong Hospital, Shanghai 200040, China.

Abstract

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide additive benefit has opened up a new chapter in therapeutic strategy and provides a basis for the development of an innovative approach for the prevention and treatment of ALI/ARDS.

PMID:
21785528
PMCID:
PMC3139183
DOI:
10.1155/2011/560194
[Indexed for MEDLINE]
Free PMC Article
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