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Nat Neurosci. 2011 Jul 24;14(9):1118-20. doi: 10.1038/nn.2880.

Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.

Author information

1
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.

PMID:
21785436
PMCID:
PMC4169194
DOI:
10.1038/nn.2880
[Indexed for MEDLINE]
Free PMC Article

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