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Autophagy. 2011 Nov;7(11):1379-81. doi: 10.4161/auto.7.11.17166. Epub 2011 Nov 1.

TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes.

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1
Telethon Institute of Genetics and Medicine, Naples, Italy.

Abstract

Autophagy is a fundamental catabolic process that plays a central role in health and disease. An efficient autophagic process relies on the cooperation of two distinct types of organelles: the autophagosome and the lysosome. We have identified a gene network that regulates the biogenesis and function of both organelles. Our findings reveal an important role of transcription in the regulation of starvation-induced autophagy, and link lysosomal biogenesis to autophagy.

PMID:
21785263
DOI:
10.4161/auto.7.11.17166
[Indexed for MEDLINE]
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