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Learn Mem. 2011 Jul 22;18(8):529-33. doi: 10.1101/lm.2253311. Print 2011 Aug.

Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats.

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1
Department of Experimental Psychology and Physiology of Behaviour, Institute of Neurosciences, Centre for Biomedical Research (CIBM), University of Granada, Campus Cartuja, 18071 Granada, Spain. fernandogamiz@ugr.es

Abstract

We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/μL) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMζ role in various forms of memory.

PMID:
21784922
DOI:
10.1101/lm.2253311
[Indexed for MEDLINE]
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