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Trends Microbiol. 2011 Sep;19(9):449-55. doi: 10.1016/j.tim.2011.06.004. Epub 2011 Jul 23.

Staphylococcal biofilm disassembly.

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1
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, MI 48109, USA.

Abstract

Staphylococcus aureus and Staphylococcus epidermidis are a frequent cause of biofilm-associated infections that are a tremendous burden on our healthcare system. Staphylococcal biofilms exhibit extraordinary resistance to antimicrobial killing, limiting the efficacy of antibiotic therapy, and surgical intervention is often required to remove infected tissues or implanted devices. Recent work has provided new insight into the molecular basis of biofilm development in these opportunistic pathogens. Extracellular bacterial products, environmental conditions, and polymicrobial interactions have all been shown to influence profoundly the ability of these bacteria to colonize and disperse from clinically relevant surfaces. We review new developments in staphylococcal biofilm disassembly and set them in the context of potential strategies to control biofilm infections.

PMID:
21784640
PMCID:
PMC3164736
DOI:
10.1016/j.tim.2011.06.004
[Indexed for MEDLINE]
Free PMC Article
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