Format

Send to

Choose Destination
J Pediatr. 2011 Dec;159(6):926-32.e2. doi: 10.1016/j.jpeds.2011.06.002. Epub 2011 Jul 23.

Benefits of supplemented preterm formulas on insulin sensitivity and body composition after discharge from the neonatal intensive care unit.

Author information

1
Neonatology Unit, Hospital Dr Sótero del Rio, Santiago, Chile.

Abstract

OBJECTIVE:

To evaluate body composition and fasting insulin level in preterm infants receiving preterm formulas (higher protein plus docosahexaenoic acid) for longer periods compared with a recent historical cohort receiving these formulas for shorter periods.

STUDY DESIGN:

A total of 95 infants fed preterm formula for 6 months or longer (postdischarge formula group) and 87 infants fed preterm formula only during their hospital stay (hospital formula group) were included in this arm of the study.

RESULTS:

Bone mineral density, content, and lean mass were not different at 1 year and 2 years. However, in the postdischarge formula group, total fat mass (%) was lower by the second year (19.3% ± 5.3% vs 21.7% ± 4.2%; P < .01), trunk fat was lower by the first year (14.7% ± 5.0% vs 16.9% ± 4.9%; P < .005) and at the second year (14.1% ± 5.7% vs 17.2% ± 4.7%; P < .001), and fasting insulin was lower by the first year (13.2% ± 7.1% vs 17.2% ± 13.6% mIU/L; P = .06) and at the second year (13.6% ± 6.1% vs 26.4% ± 14.2%; P < .001).

CONCLUSION:

Preterm infants fed formulas enriched with docosahexaenoic acid may have a better subsequent metabolic profile.

PMID:
21784447
DOI:
10.1016/j.jpeds.2011.06.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center