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Am J Obstet Gynecol. 2011 Nov;205(5):485.e17-23. doi: 10.1016/j.ajog.2011.06.019. Epub 2011 Jun 15.

Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome.

Author information

1
Department of Hematology, Guy's and St Thomas's Trust, King's College, London, UK. beverley.hunt@gstt.nhs.uk

Abstract

OBJECTIVE:

The objective of the study was to investigate whether resistance to annexin A5 anticoagulant activity (AnxA5) occurs in women with histories for obstetric complications of antiphospholipid syndrome (Obs-APS) and whether this correlates with antibody recognition of domain 1 of β2-glycoprotein.

STUDY DESIGN:

One hundred thirty-six women with antiphospholipid antibodies, including 70 with histories for Obs-APS and 30 controls, were investigated.

RESULTS:

Women with Obs-APS showed resistance to AnxA5 activity (median, 216%; range, 130-282% vs controls; median, 247%; range, 217-283%; P < .0001) and elevated levels of anti-domain I immunoglobulin (Ig) G (optical density: median, 0.056; range, 0.021-0.489 vs median, 0.042; range, 0.020-0.323; P = .002). Those in the lowest tertile of AnxA5 anticoagulant ratios had an odds ratio for Obs-APS of 58.0 (95% confidence interval, 3.3-1021.5). There was an inverse correlation between levels of annexin A5 anticoagulant activity and anti-domain I IgG.

CONCLUSION:

Resistance to AnxA5 anticoagulant activity is associated with antibody recognition of domain I of β2-glycoprotein I and identifies a subset of women with histories for Obs-APS.

PMID:
21784397
PMCID:
PMC3205287
DOI:
10.1016/j.ajog.2011.06.019
[Indexed for MEDLINE]
Free PMC Article
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