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J Am Acad Child Adolesc Psychiatry. 2011 Aug;50(8):807-17.e8. doi: 10.1016/j.jaac.2011.05.001. Epub 2011 Jul 13.

Genome-wide association study of the child behavior checklist dysregulation profile.

Author information

1
University of Massachusetts Medical School, Worcester, MA 01655, USA. eric.mick@umassmed.edu

Abstract

OBJECTIVE:

A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD).

METHOD:

Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK.

RESULTS:

CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1.

CONCLUSIONS:

We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.

PMID:
21784300
PMCID:
PMC3143361
DOI:
10.1016/j.jaac.2011.05.001
[Indexed for MEDLINE]
Free PMC Article

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