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Trends Immunol. 2011 Aug;32(8):350-7. doi: 10.1016/j.it.2011.04.009. Epub 2011 Jul 23.

Neutrophil clearance: when the party is over, clean-up begins.

Author information

1
National Jewish Health, 1400 Jackson Street, Room A540, Denver, CO 80206, USA. brattond@njhealth.org

Abstract

Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for host defense. Equally important, although less well understood, are the processes for removal of these short-lived cells. Here, we review recent findings of novel neutrophil characteristics that determine removal. These neutrophil-derived signals, in turn, can shape the responses of other cells and surrounding tissues and promote a return to homeostasis. If not removed, dying neutrophils disintegrate and release phlogistic cargo that can further contribute to ongoing inflammation, tissue destruction, or autoimmunity.

PMID:
21782511
PMCID:
PMC3151332
DOI:
10.1016/j.it.2011.04.009
[Indexed for MEDLINE]
Free PMC Article

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