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Microbiol Immunol. 1990;34(9):749-54.

A nosocomial outbreak of epidemic keratoconjunctivitis due to adenovirus type 37.

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Division of Microbiology, Yokohama City Institute of Health, Kanagawa.


An outbreak of epidemic keratoconjunctivitis occurred at the department of ophthalmology of a hospital in Yokohama, involving 14 inpatients, 12 outpatients, and 2 doctors. Adenovirus type 37 (Ad-37) was isolated from the conjunctival swab in 12 of 18 cases. In neutralization tests, the isolates showed some cross-reaction with adenovirus type 19 (Ad-19). The Ad-37 isolates were indistinguishable from each other and from the prototype Ad-37, but distinct from the prototype Ad-19 in the restriction endonuclease analysis of viral DNA.

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