Format

Send to

Choose Destination
J Thromb Haemost. 2011 Jul;9 Suppl 1:162-7. doi: 10.1111/j.1538-7836.2011.04300.x.

Nanoscale studies of protein-membrane interactions in blood clotting.

Author information

1
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. jhmorris@illinois.edu

Abstract

Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

PMID:
21781251
PMCID:
PMC3151027
DOI:
10.1111/j.1538-7836.2011.04300.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center