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J Matern Fetal Neonatal Med. 2012 Jun;25(6):747-9. doi: 10.3109/14767058.2011.591458. Epub 2011 Jul 22.

The effect of intrapartum clindamycin on vaginal group B streptococcus colony counts.

Author information

1
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Strong Memorial Hospital, USA. kristin_knight@urmc.rochester.edu

Abstract

OBJECTIVE:

To determine the temporal relationship between intrapartum clindamycin and vaginal Group B Streptococcus (GBS) colony counts.

METHODS:

In this prospective observational study, women with GBS-positive, clindamycin-sensitive, antenatal rectovaginal cultures, intrapartum vaginal cultures were collected just before the first clindamycin dose (T(0)) and then every 2ā€‰h for 8ā€‰h or until delivery. Colony counts were quantified using serial dilution. Results were standardized as percent of initial colony count and analyzed using sequential Friedman tests.

RESULTS:

Twenty-one women had positive intrapartum vaginal GBS cultures at T(0). With T(0) colony counts standardized to 100%, subsequent percents-of-baseline fell rapidly and significantly by T(2) and fell further at each subsequent point, reaching 0% by T(6). For 12 women cultured for the full 8 hours, the decline in GBS was significant at pā€‰<ā€‰0.001.

CONCLUSIONS:

Vaginal GBS colony counts fall rapidly after intrapartum clindamycin administration, similar to declines after penicillin. This represents a possible mechanism for efficacy of chemoprophylaxis.

PMID:
21780879
DOI:
10.3109/14767058.2011.591458
[Indexed for MEDLINE]

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