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J Am Chem Soc. 2011 Aug 31;133(34):13746-52. doi: 10.1021/ja205775g. Epub 2011 Aug 3.

A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids.

Author information

1
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States.

Erratum in

  • J Am Chem Soc. 2012 Mar 14;134(10):5004.

Abstract

The association between an achiral copper(II) host (1) and chiral carboxylate guests was studied using exciton-coupled circular dichroism (ECCD). Enantiomeric complexes were created upon binding of the enantiomers of the carboxylate guests to the host, and the sign of the resultant CD signal allowed for determination of the configuration of the studied guest. The difference in magnitudes and shapes of the CD signals, in conjunction with linear discriminant analysis (LDA), allowed for the identity of the guest to be determined successfully. A model was created for the host-guest complexes which successfully predicts the sign of the observed CD signal. Further, Taft parameters were used in the model, leading to rationalization of the observed magnitudes of the CD signals. Finally, the enantiomeric excess (ee) of unknown samples of three chiral carboxylic acid guests was determined with an average absolute error of ±3.0%.

PMID:
21780788
PMCID:
PMC3179184
DOI:
10.1021/ja205775g
[Indexed for MEDLINE]
Free PMC Article

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