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J Biophotonics. 2011 Aug;4(7-8):519-32. doi: 10.1002/jbio.201000088. Epub 2010 Nov 22.

Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study.

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Institute of Applied and Fundamental Medicine, Nizhny Novgorod State Medical Academy, Minina and Pozharski Sq. 10/1, Nizhny Novgorod 603005, Russia.


The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolarization simultaneously. 116 patients with localized flat suspicious lesions in the bladder were enrolled, 360 CP OCT images were obtained and analyzed. CP OCT demonstrated sensitivity 93.7% (vs. 81.2%, <0.0001), specificity 84% (vs. 70.0%, <0.001) and accuracy 85.3% (vs. 71.5%, <0.001) in detecting flat malignant bladder lesions, which is significantly better than with the traditional OCT. Higher diagnostic efficacy of CP OCT in detecting early bladder cancer is associated with the ability to detect changes in epithelium and connective tissues.

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