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Innov Clin Neurosci. 2011 Jun;8(6):15-9.

A case of probable korsakoff's syndrome: a syndrome of frontal lobe and diencephalic structural pathogenesis and a comparison with medial temporal lobe dementias.

Author information

1
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA. spiegedr@evms.edu

Abstract

Korsakoff's Syndrome is an amnestic disorder that involves both anterograde and retrograde amnesia. Traditionally associated with longstanding alcohol misuse, thiamine deficiency has been long posited in its pathogenesis, as has dienecephalic lesions. Yet, through this case report, we highlight similarities (and differences) with medial temporal lobe memory disorders and the role of frontal lobe dysfunction in its retrograde amnesia.

KEYWORDS:

Amnestic disorder; diencephalic; frontal lobe

PMID:
21779537
PMCID:
PMC3140893

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