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J Oral Maxillofac Surg. 2012 Feb;70(2):349-53. doi: 10.1016/j.joms.2011.03.026. Epub 2011 Jul 20.

Traumatic ulcerative granuloma with stromal eosinophilia: report of a case and literature review.

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Department of Basic Sciences, Dental School, University of Athens, Athens, Greece.


Traumatic eosinophilic granuloma with stromal eosinophilia is a rare entity that affects the oral mucosa and has a controversial etiologic pathogenesis. Histologically, these lesions are characterized by a dense and deeply infiltrative lymphoproliferation showing epitheliotropic characteristics and massive eosinophilia. Frequently, a population of mitotically active, atypical mononuclear cells can be noted. This report describes a case of traumatic eosinophilic granuloma with stromal eosinophilia in the floor of the mouth of an 88-year-old man. The phenotypic and genotypic profiles of the inflammatory infiltrate and large atypical mononuclear cells, using immunohistochemical and polymerase chain reaction-based molecular analysis, were analyzed.

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