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Fundam Clin Pharmacol. 2012 Apr;26(2):190-3. doi: 10.1111/j.1472-8206.2011.00928.x.

Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.

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Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.

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