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J Signal Transduct. 2011;2011:768512. doi: 10.1155/2011/768512. Epub 2011 Apr 7.

Erk in kidney diseases.

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Division of Nephrology, Department of Medicine, O'Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, TX 78229, USA.


Acute or chronic kidney injury results from various insults and pathological conditions, and is accompanied by activation of compensatory repair mechanisms. Both insults and repair mechanisms are initiated by circulating factors, whose cellular effects are mediated by activation selective signal transduction pathways. Two main signal transduction pathways are activated during these processes, the phosphatidylinositol 3' kinase (PI-3K)/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) cascades. This review will focus on the latter, and more specifically on the role of extracellular signal-regulated kinase (ERK) cascade in kidney injury and repair.

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