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J Med Life. 2011 May 15;4(2):126-38. Epub 2011 May 25.

Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation.

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Foothills Medical Centre, Department of Pathology, Calgary, AB, T2N 2T9, Canada.


This review summarizes recent advances in our understanding of neuronal T-type calcium channel regulation as well as their physiological and pathophysiological roles. Through their ability to conduct calcium across the cellular membrane at potentials close to the resting potential, T-type calcium channels are critically important for regulating neuronal excitability, both in the central and peripheral nervous system. T-type channels are also linked to an increasing number of neurological disorders such as the absence epilepsy and neuropathic pain. Although there is substantial literature dealing with regulation of native T-type channels, the underlying molecular mechanism has only recently been addressed. It is, therefore, critical to understand the cellular mechanisms that control T-type channel activity and expression, because this could provide important insight into designing novel therapeutic strategies targeting these channels.


T–type; calcium channel; epilepsy; pain; sleep

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