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Clin Dev Immunol. 2011;2011:346307. doi: 10.1155/2011/346307. Epub 2011 Jun 23.

Mucosal immunity and Candida albicans infection.

Author information

1
Department of Oral Immunology, King's College London Dental Institute, King's College London, Floor 28, Tower Wing, London SE1 9RT, UK.

Abstract

Interactions between mucosal surfaces and microbial microbiota are key to host defense, health, and disease. These surfaces are exposed to high numbers of microbes and must be capable of distinguishing between those that are beneficial or avirulent and those that will invade and cause disease. Our understanding of the mechanisms involved in these discriminatory processes has recently begun to expand as new studies bring to light the importance of epithelial cells and novel immune cell subsets such as T(h)17 T cells in these processes. Elucidating how these mechanisms function will improve our understanding of many diverse diseases and improve our ability to treat patients suffering from these conditions. In our voyage to discover these mechanisms, mucosal interactions with opportunistic commensal organisms such as the fungus Candida albicans provide insights that are invaluable. Here, we review current knowledge of the interactions between C. albicans and epithelial surfaces and how this may shape our understanding of microbial-mucosal interactions.

PMID:
21776285
PMCID:
PMC3137974
DOI:
10.1155/2011/346307
[Indexed for MEDLINE]
Free PMC Article

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