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Panminerva Med. 2011 Sep;53(3):185-91.

Spray formulation of silver and hyaluronic acid in the treatment of superficial cutaneous ulcers of different etiopathogenesis: analysis of fifty-four clinical cases.

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Department of General Surgery, Center of Diagnosis and Treatment of Vascular Ulcers, Villa Fiorita Clinic, Prato, Italy.



The aim of this study was to assess a spray formulation containing colloidal silver and hyaluronic acid.


Patients included in the study were divided in two separate groups: 30 patients had chronic wounds and 24 patients had superficial traumatic wounds. Applications were performed at intervals of 3-7 days, depending upon lesions characteristics. Subsequent improvements were evaluated at various intervals after enrollment. The lesion area and the rate of re-epithelialization were calculated, considering the time span and monitoring the patients for clinical signs of wound infection. Patients satisfaction and compliance were evaluated by a questionnaire aimed at assessing pain and ease of use of the device.


Chronic lesions were healed at week 12, with a high rate of closure observed at 6 weeks (70%). Furthermore, traumatic wounds healed at six weeks, with a substantial percentage of closure (80%) at three weeks. A good control of microbial contamination was evident in all the treated wounds; in no case other antimicrobial medications were used. Finally, patients favorably expressed compliance with regard to the spray formulation and ease of use.


This type of clinical approach seems to be a rational good choice to promote re-epithelialization of superficial cutaneous ulcers of different origins as well as control of bacterial infections.

[Indexed for MEDLINE]

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