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Learn Mem. 2011 Jul 20;18(8):523-8. doi: 10.1101/lm.2135211. Print 2011 Aug.

Associative retrieval processes in the human medial temporal lobe: hippocampal retrieval success and CA1 mismatch detection.

Author information

1
Department of Psychology, Stanford University, Stanford, California 94305, USA. kanile@stanford.edu

Abstract

Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA(2/3), CA(1), and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA(1) and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.

PMID:
21775513
PMCID:
PMC3256570
DOI:
10.1101/lm.2135211
[Indexed for MEDLINE]
Free PMC Article

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