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J Cosmet Laser Ther. 2011 Oct;13(5):237-42. doi: 10.3109/14764172.2011.606466.

Effect of low-level laser therapy (660 nm) on the healing of second-degree skin burns in rats.

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1
Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil. acmr_ft@yahoo.com.br

Abstract

The aim of this study was to investigate the effects of 660 nm laser on the healing of burn wounds made on the backs of rats. Thirty-two Wistar male rats were used. The animals were randomly distributed into 2 groups of 16 animals each: control group (burned rats without treatment) and laser-treated group (burned rats treated with laser therapy). Each group was divided into two different subgroups, euthanized in different periods (subgroup A: 7 days post-surgery and subgroup B: 14 days post-surgery). Histopathological analysis revealed a significant decrease in the necrotic area in the laser-treated group compared to the controls at days 7 and 14 post-injury. COX-2 positive cells were found in a strong pattern in the group submitted to laser therapy after 7 days. Regarding VEGF immunomarker, a significant VEGF immunoexpression was detected in the laser-exposed group after 14 days when compared to the negative control group. Taken together, our results demonstrate that laser therapy is able to promote skin repair of burned rats as a result of decreasing necrotic area and an up-regulation of COX-2 and VEGF immunoexpression.

PMID:
21774661
DOI:
10.3109/14764172.2011.606466
[Indexed for MEDLINE]

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