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Am J Hum Biol. 2011 Nov-Dec;23(6):820-2. doi: 10.1002/ajhb.21205. Epub 2011 Jul 19.

Measurement of testosterone in infant fecal samples.

Author information

1
Department of Anthropology, University of North Carolina at Chapel Hill, USA. althomps@email.unc.edu

Abstract

OBJECTIVES:

This study reports the validation of a noninvasive method for repeated assessment of testosterone from infant fecal samples.

METHODS:

Fecal samples were collected from cotton diaper liners, subjected to methanol extraction, and assayed using a modified commercial testosterone RIA kit.

RESULTS:

Method validity was supported by a recovery near 100%, a sensitivity of 1.23 pg/ml, and inter- and intra-assay coefficients of variations less than 10 and 15%, respectively. Testosterone was detected in all samples from male and female infants aged 2 weeks to 15 months.

CONCLUSIONS:

Fecal assessment is supported as a novel, non-invasive tool for studying testosterone during early human development.

PMID:
21774027
DOI:
10.1002/ajhb.21205
[Indexed for MEDLINE]

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