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Cancer Causes Control. 2011 Oct;22(10):1453-9. doi: 10.1007/s10552-011-9820-x. Epub 2011 Jul 20.

The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study.

Author information

1
Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA 02130, USA. wfarwell@gmail.com

Abstract

OBJECTIVE:

We examined the relationship between height and prostate cancer grade.

METHODS:

The Early Stage Prostate Cancer Cohort Study is an observational cohort of 1,037 men diagnosed with early-stage prostate cancer, T(0-3)N(x)M(0). High-grade prostate cancer was defined as a biopsy Gleason score ≥ 7 (4 + 3). Logistic regression models were created to calculate odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional relationship between height and prostate cancer grade in the overall cohort and subpopulations.

RESULTS:

We identified 939 participants with a biopsy Gleason score. High-grade prostate cancer was diagnosed in 138 participants. Overall, participants in the highest quartile of height were more than twice as likely to have a Gleason score ≥ 7 (4 + 3) than participants in the lowest quartile of height, OR 2.14 (95% CI 1.11, 4.14), after multivariate adjustment. Participants in the highest quartile of height were more likely to be diagnosed with high-grade prostate cancer than participants in the lowest quartile of height among participants who were black, OR 8.00 (95% CI 1.99, 32.18), and participants who had diabetes mellitus, OR 5.09 (95% CI 1.30, 19.98).

CONCLUSIONS:

Height is associated with increased risk of high-grade prostate cancer overall and perhaps among certain subpopulations.

PMID:
21773817
PMCID:
PMC4428304
DOI:
10.1007/s10552-011-9820-x
[Indexed for MEDLINE]
Free PMC Article

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