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Chem Commun (Camb). 2011 Sep 7;47(33):9405-7. doi: 10.1039/c1cc12879e. Epub 2011 Jul 20.

SNARE derived peptide mimic inducing membrane fusion.

Author information

1
Institut für Organische und Biomolekulare Chemie, Tammannstr. 2, 37077 Göttingen, Germany.

Abstract

SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

PMID:
21773636
DOI:
10.1039/c1cc12879e
[Indexed for MEDLINE]

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