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Pharmacognosy Res. 2011 Apr;3(2):143-5. doi: 10.4103/0974-8490.81964.

Chemical constituents and biological studies of Origanum vulgare Linn.

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CavinKare Research Centre, Ekkattuthangal, Chennai - 600 032, India.


Bioassay-guided isolation of methanolic extract of the leaves of Origanum vulgare Linn., yielded two protocatechuic acid ester derivatives, origanol A (1) and origanol B (2) along with ursolic acid (3), oleanolic acid (4), β-sitosterol (5), and triacontanol (6). Structures of the compound were established based on physical and spectral data (UV, IR, (1)H and (13)C NMR and mass). Origanol A (1) showed significant mushroom tyrosinase inhibition activity.


Origanum vulgare Linn.; origanol A and B; triterpene acids; tyrosinase inhibition; β-sitosterol

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