Format

Send to

Choose Destination
Mediators Inflamm. 2011;2011:652097. doi: 10.1155/2011/652097. Epub 2011 May 3.

Potential role of nuclear factor κB in diabetic cardiomyopathy.

Author information

1
Vascular Pathology Laboratory, Instituto de Investigaciones Sanitarias IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, Madrid 28040, Spain. olorenzo@fjd.es

Abstract

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

PMID:
21772665
PMCID:
PMC3136091
DOI:
10.1155/2011/652097
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center