Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurosci. 2011 Jul 20;12(8):437-52. doi: 10.1038/nrn3068.

Fighting neurodegeneration with rapamycin: mechanistic insights.

Author information

1
Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute-CIBERNED, 08035 Barcelona, Spain.

Abstract

A growing number of studies point to rapamycin as a pharmacological compound that is able to provide neuroprotection in several experimental models of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and spinocerebellar ataxia type 3. In addition, rapamycin exerts strong anti-ageing effects in several species, including mammals. By inhibiting the activity of mammalian target of rapamycin (mTOR), rapamycin influences a variety of essential cellular processes, such as cell growth and proliferation, protein synthesis and autophagy. Here, we review the molecular mechanisms underlying the neuroprotective effects of rapamycin and discuss the therapeutic potential of this compound for neurodegenerative diseases.

PMID:
21772323
DOI:
10.1038/nrn3068
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center