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Nat Immunol. 2011 Jul 19;12(8):715-23. doi: 10.1038/ni.2060.

Inflammation meets cancer, with NF-κB as the matchmaker.

Author information

1
Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel. yinon@cc.huji.ac.il

Abstract

Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.

PMID:
21772280
DOI:
10.1038/ni.2060
[Indexed for MEDLINE]
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