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Pediatr Infect Dis J. 2011 Sep;30(9):801-4. doi: 10.1097/INF.0b013e3182196ab4.

Impact of human immunodeficiency virus coinfection on the progression of mother-to-child transmitted hepatitis C virus infection.

Author information

1
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. ton@hsjdbcn.org

Abstract

Data on mother-to-child transmitted human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection are scarce. A prospective observational study with a cohort of 70 HCV-infected children (13 of whom were HIV/HCV-coinfected; mean follow-up: 7.3 years) is presented. In our series, surrogate markers of disease progression (HCV viremia, maximum alanine aminotransferase values, and spontaneous HCV infection clearance) suggest that the evolution of liver disease in HIV/HCV-coinfected pediatric patients is more aggressive than it is in HCV-only infected children.

PMID:
21772231
DOI:
10.1097/INF.0b013e3182196ab4
[Indexed for MEDLINE]

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