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BMC Syst Biol. 2011 Jul 19;5:115. doi: 10.1186/1752-0509-5-115.

Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue.

Author information

1
Niels Bohr Institute, Copenhagen, Denmark. trusina@nbi.dk

Abstract

BACKGROUND:

Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.

RESULTS:

We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.

CONCLUSIONS:

While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

PMID:
21771307
PMCID:
PMC3152534
DOI:
10.1186/1752-0509-5-115
[Indexed for MEDLINE]
Free PMC Article

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