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Anal Chem. 2011 Oct 1;83(19):7234-41. doi: 10.1021/ac200567u. Epub 2011 Aug 1.

Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.

Author information

1
Center for Proteomics & Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Abstract

Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.

PMID:
21770468
PMCID:
PMC3184339
DOI:
10.1021/ac200567u
[Indexed for MEDLINE]
Free PMC Article

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