Format

Send to

Choose Destination
Arthritis Rheum. 2011 Nov;63(11):3531-9. doi: 10.1002/art.30535.

Improving the detection of pulmonary hypertension in systemic sclerosis using pulmonary function tests.

Author information

1
Royal Free Hampstead NHS Trust, London, UK. benjamin.schreiber@nhs.net

Abstract

OBJECTIVE:

To construct a readily applicable formula for selecting patients with systemic sclerosis (SSc) for right-sided heart catheterization (RHC) based on the results of their pulmonary function tests (PFTs).

METHODS:

The diagnostic value of PFT variables was quantified in 386 patients with SSc against data obtained from RHC.

RESULTS:

We derived the following formula using data from 257 patients: predicted mPAP = 136 - SpO₂ - 0.25 × DLCO % predicted, where mPAP is the mean pulmonary artery pressure, SpO₂ is the oxygen saturation as measured by pulse oximetry, and DLCO is the diffusing capacity for carbon monoxide. We validated the formula in the remaining 129 SSc patients. The area under the curve was 0.75 (95% confidence interval [95% CI] 0.67, 0.84). Using a predicted threshold of 25 mm Hg, the sensitivity was 90.1% (95% CI 82, 96) and the specificity was 29.2% (95% CI 17, 44). When used as a screening procedure in a typical scleroderma patient population, it is projected that those with an mPAP below 25 mm Hg are unlikely to have pulmonary hypertension (PH; prevalence 4.4%), those with a predicted mPAP of 25-35 mm Hg are at average risk of having PH (prevalence of 11.3%), and those with a formula-predicted mPAP above 35 mm Hg are likely to have PH (prevalence of 62.9%), thus justifying RHC. In patients with equivocal findings on echocardiography, a high formula-predicted mPAP is strongly associated with the presence of PH.

CONCLUSION:

We derived and validated an easily applied formula for determining pulmonary function in patients with SSc that identifies subgroups with a low, average, or high prevalence of PH. It provides information that is complementary to echocardiography and that should improve the selection of patients for RHC.

PMID:
21769839
DOI:
10.1002/art.30535
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center