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Eur J Appl Physiol. 2012 Apr;112(4):1215-20. doi: 10.1007/s00421-011-2072-3. Epub 2011 Jul 17.

Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study.

Author information

1
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N. Broadway, Baltimore, MD 21287, USA. rdsemba@jhmi.edu

Abstract

Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.

PMID:
21769735
PMCID:
PMC3435096
DOI:
10.1007/s00421-011-2072-3
[Indexed for MEDLINE]
Free PMC Article

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