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Top Curr Chem. 2011;305:79-99. doi: 10.1007/128_2011_166.

Transgenic mouse models and prion strains.

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1
Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, KY 40506, USA. gtell2@uky.edu

Abstract

Here we review the known strain profiles of various prion diseases of animals and humans, and how transgenic mouse models are being used to elucidate basic molecular mechanisms of prion propagation and strain variation and for assessing the zoonotic potential of various animal prion strains.

PMID:
21769720
DOI:
10.1007/128_2011_166
[Indexed for MEDLINE]
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