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Bioinformation. 2011;6(8):297-9. Epub 2011 Jul 6.

Annotation of hypothetical proteins orthologous in Pongo abelii and Sus scrofa.

Abstract

A hypothetical protein is predicted to be expressed from an open reading frame without known experimental evidence of translation. They constitute a substantial fraction of proteomes. Domain extraction from these hypothetical sequences helps to search for protein coding genes for protein structural and functional annotation. We describe the analysis of prediction data in a sequence dataset of hypothetical protein orthologs of Pongo abelii (orangutan) and Sus scrofa (pig). It should be noted that these orangutan-pig orthologs are also non-homologous to human proteins. These predicted data find application in the genome wide annotation of proteins in poorly understood genomes.

ABBREVIATIONS:

PDB - Protein Data Bank, DEG - Database of Essential Genes, CDD - Conserved Domain Database, IUCN - International Union for Conservation of Nature.

KEYWORDS:

Pongo abelii; Sus scrofa; functional annotation; hypothetical proteins; structure prediction; subcellular localization

PMID:
21769189
PMCID:
PMC3134776
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