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Obstet Gynecol. 2011 Aug;118(2 Pt 2):461-3. doi: 10.1097/AOG.0b013e3182164af8.

Pagetoid adenocarcinoma in situ of the cervix with pagetoid spread into the vagina.

Author information

1
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98195, USA. mahdih@uw.edu

Abstract

BACKGROUND:

Pagetoid spread of adenocarcinoma in situ of the cervix into vaginal epithelium is a rare phenomenon, mimicking Paget's disease of the vulva.

CASE:

We report a case of in situ squamous cell and in situ adenocarcinoma of the cervix in a 44-year-old woman who underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and upper vaginectomy. Pathologic evaluation showed pagetoid endocervical adenocarcinoma in situ spreading into the vagina with positive margins. Malignant cells were positive for mucin, P16, CK-7, and carcinoembryonic antigen.

CONCLUSION:

The asymptomatic occult finding of pagetoid changes in the vagina should raise the suspicion of vaginal extension of pagetoid genital or urothelial carcinoma in situ; however, it can be mistaken as vaginal dysplasia or primary Paget's disease. Immunohistochemical profiling may help in the differential diagnosis.

PMID:
21768854
DOI:
10.1097/AOG.0b013e3182164af8
[Indexed for MEDLINE]
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