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Cephalalgia. 2011 Sep;31(12):1315-9. doi: 10.1177/0333102411414442. Epub 2011 Jul 18.

Head tremor related to CACNA1A mutations.

Author information

1
Department of Neurology, Atrium Medical Centre, Heerlen, The Netherlands.

Abstract

INTRODUCTION:

Familial hemiplegic migraine (FHM) is characterized by the familial occurrence of migraine attacks with fully reversible transient hemiplegia. Mutations in three different genes have been identified; CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3). Besides hemiplegia, several other symptoms have been described in FHM 1-3 mutation carriers, including epilepsy and cerebellar symptoms.

CASE REPORT:

We describe two patients in whom hemiplegic attacks were not the presenting symptom, but in whom an otherwise unexplained head tremor led us to search for FHM mutations. Both patients carried a mutation in the CACNA1A gene.

DISCUSSION:

CACNA1A mutations can give significant symptoms other than (hemiplegic) migraine as reason for presentation.

PMID:
21768184
DOI:
10.1177/0333102411414442
[Indexed for MEDLINE]

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