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Diagn Microbiol Infect Dis. 2011 Aug;70(4):549-53. doi: 10.1016/j.diagmicrobio.2011.04.007.

Characterization of a novel extended-spectrum β-lactamase phenotype from OXA-1 expression in Salmonella Typhimurium strains from Africa and Ireland.

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1
School of Medicine, National University of Ireland, Galway, Ireland. fiona.boyle@nuigalway.ie

Abstract

Salmonella enterica (S. Typhimurium) strains from Kenya, Malawi, and Ireland showing elevated cefepime MIC values carried bla(OXA-1). These strains were not detected by current guidelines for extended-spectrum β-lactamase production based on MIC values or clavulanate inhibition, since cefepime is a preferred substrate for OXA-1 and this enzyme is reported to be resistant to clavulanate inhibition. bla(OXA-1) was located within a class I integron and an activated P(2) promoter was identified upstream of bla(OXA-1). P(2) was activated by the insertion of a triplet 'GGG' upstream of the -10 signal. All African strains were ST313, prevalent in this continent, and the Irish isolate belonged to ST19.

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