Format

Send to

Choose Destination
See comment in PubMed Commons below
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):103-15. doi: 10.1002/wsbm.155. Epub 2011 Jul 15.

Modeling of spatially-restricted intracellular signaling.

Author information

1
Department of Pharmacology and System Therapeutics, Friedman Brain Institute, Systems Biology Center of New York, Mount Sinai School of Medicine, New York, NY, USA. susana.neves@mssm.edu

Abstract

Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but also because of the complex network connectivity of intracellular signaling. Recently, the proliferation of quantitative imaging techniques has led to the discovery of the vast spatial organization of intracellular signaling. Computational modeling has emerged as a powerful tool for understanding how inhomogeneous signaling originates and is maintained. This article covers the current imaging techniques used to obtain quantitative spatial data and the mathematical approaches used to model spatial cell biology. Modeling-derived hypotheses have been experimentally tested and the integration of modeling and imaging approaches has led to non-intuitive mechanistic insights.

PMID:
21766466
PMCID:
PMC4108591
DOI:
10.1002/wsbm.155
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center