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J Thyroid Res. 2011;2011:145762. doi: 10.4061/2011/145762. Epub 2011 Jun 16.

Thyroid hormone action in cerebellum and cerebral cortex development.

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1
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR CNRS 5242, 46 allée d'Italie, 69364 Lyon Cedex 07, France.

Abstract

Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3',5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.

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