Format

Send to

Choose Destination
J Biomed Biotechnol. 2011;2011:978312. doi: 10.1155/2011/978312. Epub 2011 Jun 16.

Recent advances in p53 research and cancer treatment.

Author information

1
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. suzuki@chiba-u.jp

Abstract

TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53-based therapy for human cancer.

PMID:
21765642
PMCID:
PMC3134396
DOI:
10.1155/2011/978312
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center