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Nat Rev Microbiol. 2011 Jul 18;9(9):635-46. doi: 10.1038/nrmicro2602.

Manipulation of host membranes by bacterial effectors.

Author information

1
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Abstract

Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.

PMID:
21765451
DOI:
10.1038/nrmicro2602
[Indexed for MEDLINE]

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