Send to

Choose Destination
Genes Chromosomes Cancer. 1990 Nov;2(4):266-70.

Chromosomal localization of the human myeloperoxidase gene by in situ hybridization using oligonucleotide probes.

Author information

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia.


Oligonucleotide probes have been used to map the myeloperoxidase (MPO) gene locus to chromosome bands 17q21-22. This is in agreement with results reported using conventional cDNA probes. No evidence for the existence of a second MPO gene locus was obtained. Six synthetic 72-base oligonucleotides, corresponding to different exon regions of the MPO gene, were tritium-labeled and used as in situ hybridization probes. Synthetic oligonucleotide probes offer a useful alternative to conventional DNA probes for gene mapping.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center