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Bioinformatics. 2011 Sep 1;27(17):2448-50. doi: 10.1093/bioinformatics/btr423. Epub 2011 Jul 15.

IRiS: construction of ARG networks at genomic scales.

Author information

1
Computational Biology Center, IBM T J Watson Research, Yorktown Heights, NY 10598, USA.

Abstract

SUMMARY:

Given a set of extant haplotypes IRiS first detects high confidence recombination events in their shared genealogy. Next using the local sequence topology defined by each detected event, it integrates these recombinations into an ancestral recombination graph. While the current system has been calibrated for human population data, it is easily extendible to other species as well.

AVAILABILITY:

IRiS (Identification of Recombinations in Sequences) binary files are available for non-commercial use in both Linux and Microsoft Windows, 32 and 64 bit environments from https://researcher.ibm.com/researcher/view_project.php?id = 2303

CONTACT:

parida@us.ibm.com.

PMID:
21765095
DOI:
10.1093/bioinformatics/btr423
[Indexed for MEDLINE]

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