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Curr Opin Neurobiol. 2011 Oct;21(5):782-90. doi: 10.1016/j.conb.2011.06.009. Epub 2011 Jul 18.

The computational worm: spatial orientation and its neuronal basis in C. elegans.

Author information

1
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA. shawn@uoregon.edu

Abstract

Spatial orientation behaviors in animals are fundamental for survival but poorly understood at the neuronal level. The nematode Caenorhabditis elegans orients to a wide range of stimuli and has a numerically small and well-described nervous system making it advantageous for investigating the mechanisms of spatial orientation. Recent work by the C. elegans research community has identified essential computational elements of the neural circuits underlying two orientation strategies that operate in five different sensory modalities. Analysis of these circuits reveals novel motifs including simple circuits for computing temporal derivatives of sensory input and for integrating sensory input with behavioral state to generate adaptive behavior. These motifs constitute hypotheses concerning the identity and functionality of circuits controlling spatial orientation in higher organisms.

PMID:
21764577
PMCID:
PMC3947813
DOI:
10.1016/j.conb.2011.06.009
[Indexed for MEDLINE]
Free PMC Article

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